ABSTRACT: The rise of interactions between wildlife and humans increases the need to understand the relationship between different ecological and epidemiological processes within and among different interacting populations. Foot-and-mouth disease viruses (FMDV) are among the most infectious pathogens known to man, and Wild buffalo (Syncerus caffer) act as a reservoir host for FMDV in the sub-Saharan region of the African continent. Because of the impact on international livestock trade that Foot-and-mouth disease can cause, and its ubiquitous characteristic of persisting in wild populations of African buffalo while remaining highly contagious, raises the question of how this pathogen persists in the wild. In this talk, we will discuss current modeling work concerning the propagation of FMDVs in their reservoir host, through a modified McKendrick–von Foerster equation solved through the Crank-Nicolson method. We consider the dynamics for the loss of acquired immunity, its role in the facilitation and stabilization of the persistence of this fast-spreading pathogen in wildlife populations, and how some of this pathogen's evolutionary mechanisms affect its epidemic dynamics.