Event Detail

Event Type: 
Mathematical Biology Seminar
Date/Time: 
Wednesday, April 25, 2018 - 16:00 to 17:00
Location: 
GILK 100

Speaker Info

Abstract: 

Kinesin-14s – kinesin motor proteins with a C-terminal motor domain – are commonly considered to be nonprocessive minus-end-directed motor, as they exhibit directional preference toward the microtubule minus ends in ensembles but are unable to generate processive (continuous) motility as individual homodimers'. In this talk, I will present several unexpected findings from my lab to show that the canonical view that “kinesin-14s are nonprocessive minus-end-directed motors” no longer holds true. In particular, I will show that: 1) OsKCH2, a kinesin-14 motor from the rice plant, contains the ability to exhibit processive minus-end-directed motility on single microtubules as a homodimer; and 2) KlpA, a kinesin-14 motor from Aspergillus nidulans, exhibits processive plus-end-directed motility on single microtubules and switch to the canonic minus-end-directed motility between two different microtubules. Our results markedly expand current view of the design and operation principles of kinesin-14 motors.