Dengue is a mosquito-borne viral pathogen that causes large amounts of
disease in the tropics and sub-tropics. Two new interventions for
dengue are currently in intense development: a vaccine that protects
against all four serotypes and transgenic mosquitoes that are
less-suitable vectors. We developed a mathematical model for
evolution of dengue viruses in response to these new interventions. I
will discuss results from the model, including interventions that
would pose the least risk of selecting for more virulent dengue
strains.