Event Detail

Event Type: 
Mathematical Biology Seminar
Date/Time: 
Thursday, March 5, 2015 - 12:00 to 13:00
Location: 
WNGR 201

Speaker Info

Abstract: 

Kinesins are nanometer-sized biological motors that use the energy of ATP hydrolysis to move along the surface of track-like structures called microtubules or exert mechanical forces inside cells. Kinesin activities are essential for many cellular processes including the transport of cargos such as organelles and proteins, the organization and maintenance of the cytoskeleton and the segregation of genetic material during mitosis and meiosis. When not transporting cargos or exerting forces, the motor activity of a kinesin must be tightly controlled to prevent futile ATP hydrolysis and the congestion of microtubule tracks. In this presentation, I will discuss how we, using an interdisciplinary approach combining molecular biology, protein biochemistry and single molecule TIRF microscopy, begin to show that several members in the kinesin-4 subfamily are controlled via an autonomous regulatory mechanism.