Climate related shifts in water temperatures and precipitation patterns will likely have important effects on the dynamics of myxozoan disease but predicting the magnitude and direction of specific responses is challenging. I will present an overview of myxozoan disease dynamics in the context of climate change illustrated with data from a case study on disease (ceratomyxosis) dynamics in Klamath River salmonids. We are currently exploring the use of models to predict responses of Ceratonova (syn Ceratomyxa) shasta in different types of water years (dry, median, wet) and climates (hot/dry, moderate/median, and cold/wet). The focus of this talk will be on the current version of the epidemiological model- including the empirical data we have collected and the statistical models we have built to provide values for parameterizing the variables that are more difficult to measure. My aim is to contrast the aspects of the current model that work well with those that don’t well describe the system in hopes that you may provide some feedback for improvement!