Mathematics

I will describe recent progress in interpretation and modeling of super-resolution light microscopy applied to immune cell surface receptor organization and dynamics. The main experimental tools I will describe will be STochastic Optical Reconstruction Microscopy (STORM) and Single Particle Tracking (SPT). Over the last few years I have been working on model-based mathematical and computational methods to understand the information coming from these experimental techniques. In this talk I’ll describe the biological context and experimental set-up, and then move on to show how stochastic modeling approaches based primarily on hidden Markov methods can help with interpretation.