Event Detail

Event Type: 
Mathematical Biology Seminar
Wednesday, January 24, 2018 - 16:00 to 17:00
GILK 100

Speaker Info

University of Washington

This talk is a recording made by the MBI at Ohio State University: https://mbi.osu.edu/event/?id=1071

A major goal of genetic analysis is to find the genes that underlie traits of medical or economic importance. The associations between trait data and marker DNA arise from the descent of genome to related individuals. Thus, we consider these associations through analyses of relatedness as measured by shared ancestry of genome, or identity by descent (IBD). To achieve this, we present models for IBD both among individuals and across the genome, and thence a framework for realizations of IBD given genome-wide marker data. In general, model-based probabilities of trait data jointly on individuals depend only on the joint IBD among them at the relevant loci. We consider the particular case of a variance component model for a quantitative trait, where only location-specific pairwise relatedness between individuals is required.